Infanrix Hexa Caution For Usage

Incompatibilities: Infanrix hexa should not be mixed with other vaccines in the same syringe.
Use and Handling: The DTPa-HBV-IPV suspension should be well shaken in order to obtain a homogeneous turbid white suspension. The DTPa-HBV-IPV suspension and the Hib powder should be inspected visually for any foreign particulate matter and/or variation of physical aspect. In the event of either being observed, do not administer the vaccine.
Infanrix hexa must be reconstituted by adding the entire content of the pre-filled syringe to the vial containing the Hib powder. The mixture should be well shaken until the powder is completely dissolved in the suspension.
It is good clinical practice to only inject a vaccine when it has reached room temperature. In addition, a vial at room temperature ensures sufficient elasticity of the rubber closure to minimise any coring of rubber particles. To achieve this, the vial should be kept at room temperature (25 ± 3 °C) for at least five minutes before connecting the pre-filled syringe and reconstituting the vaccine.
The reconstituted vaccine presents as a slightly more cloudy suspension than the liquid component alone. This is a normal observation.
The reconstituted vaccine should be inspected visually for any foreign particulate matter and/or abnormal physical appearance. In the event of either being observed, do not administer the vaccine.
After reconstitution, the vaccine should be injected immediately. However the vaccine may be kept for up to 8 hours at room temperature (21°C).
Withdraw the entire content of the vial.
Specific instructions for the pre-filled syringe with a luer lock adaptor (PRTC): 1. Holding the syringe barrel in one hand (avoid holding the syringe plunger), unscrew the syringe cap by twisting it anticlockwise.
2. To attach the needle to the syringe, twist the needle clockwise into the syringe until it feels locked.
3. Remove the needle protector, which on occasion can be a little stiff.
4. Reconstitute the vaccine as described previously.
Any unused product or waste material should be disposed of in accordance with local requirements.